22

Hoog R, Lima V, Sterne JA et al (2008) Life expectancy of individuals on combination antiretro­

viral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet

372(9635):293–299. https://doi.org/10.1016/S0140-­6736(08)61113-­7

Further Reading

Altschul SF, Madden TL, Schäffer AA et al (1997) Gapped BLAST and PSI-BLAST: a new gen­

eration of protein database search programs. Nucleic Acids Res 25(17):3389–3402 (Review.

PubMed PMID: 9254694 *The classic 1990 paper on the best-known sequence comparison

algorithm, the Basic Alignment Sequence Research Tool [BLAST]. Surprisingly, it was not until

1997 that gaps were considered [“gapped BLAST”], and it became possible to repeat the search

with multiple sequences if the function was not yet clear [“position specific iterative” BLAST

or psi-BLAST])

Bienert S, Waterhouse A, Beer TA de et al (2017) The SWISS-MODEL Repository-new features

and functionality. Nucleic Acids Res 45(D1):D313–D319. https://doi.org/10.1093/nar/gkw1132

(PubMed PMID: 27899672; PubMed Central PMCID: PMC5210589 *This is the latest version of

the homology program Swiss-Model, a very convenient program that predicts from the sequence

of a protein its three-dimensional structure, just send by e-mail the sequence to the server)

Gaudermann P, Vogl I, Zientz E et al (2006) Analysis of and function predictions for previously con­

served hypothetical or putative proteins in Blochmannia floridanus. BMC Microbiol 2006(6):1

(*This paper provides a good introduction to how one can still determine the function of a protein

with sequence and structural analyses, even if BLAST initially finds no evidence of function)

Gupta SK, Bencurova E, Srivastava M et al (2016) Improving re-annotation of annotated eukaryotic

genomes. In: Wong K-C (Herausgeber) Big data analytics in genomics. Springer, S171–195.

https://link.springer.com/chapter/10.1007%2F978-­3-­319-­41279-­5_5 (*In this work, we explain

how to improve annotation [labeling] in a higher [eukaryotic] genome)

NCBI Resource Coordinators (2017) Database resources of the National Center for Biotechnology

Information. Nucleic Acids Res 45(D1):D12–D17. doi:https://doi.org/10.1093/nar/gkw1071

(PubMed PMID: 27899561; PubMed Central PMCID: PMC5210554 *This explains the bioin­

formatics opportunities at NCBI, the world’s premier bioinformatics entry site)

SIB Swiss Institute of Bioinformatics Members (2016) The SIB Swiss Institute of Bioinformatics’

resources: focus on curated databases. Nucleic Acids Res 44(D1):D27–D37. doi:https://doi.

org/10.1093/nar/gkv1310 (*Hier werden die Bioinformatik-Möglichkeiten am Schweizer

Bioinformatik-Institut erklärt)

Srivastava M, Malviya N, Dandekar T (2015) Application of biotechnology and bioinformatics tools

in plant-fungus interactions. In: Bahadur B, Rajam MV, Sahijram L, Krishnamurthy KV (Hrsg)

Plant Biol Biotechnol. Springer India, S 49–64 (*Here we explain how to bioinformatically study

protein interactions)

1  Sequence Analysis: Deciphering the Language of Life